Tom Lab

Studying how to promote functional recovery after spinal cord injury


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Matamoros AJ, Tom VJ, Wu Di, Rao Y, Sharp DJ, Baas PW (2019). Knockdown of fidgetin improves regeneration of injured axons by a microtubule-based mechanism. J. Neurosci. 39: 2011-2024. PMID: 30647150

Mironets E, Osei-Owusu P, Bracchi-Ricard V, Fischer R, Owens EA, Ricard J, Wu D, Saltos T, Collyer E, Hou S, Bethea JR, Tom VJ (2018). Soluble TNFa signaling within the spinal cord contributes to the development of autonomic dysreflexia and ensuing vascular and immune dysfunction after spinal cord injury. J. Neurosci. 38: 4146-4162. PMID: 29610439

Wu D, Klaw MC, Connors T, Kholodilov N, Burke RE, Cote, MP, Tom VJ (2017). Combining constitutively active rhea expression and chondroitinase promotes functional axonal regeneration after cervical spinal cord injury. Mol Ther. 25: 2715-2726. PMID: 28967557

Hou S, Saltos TM, Iredia IW, Tom VJ (2018). Surgical techniques influence local environment of injured spinal cord and cause various grafted cell survival and integration. J Neurosci Methods. 293: 144-150. PMID: 28947264

Wang Z, Nong J, Shultz RB, Zhang Z, Kim T, Tom VJ, Ponnappan RK, Zong Y (2017). Local delivery of minocycline from metal ion-assisted self-assembled complexes promotes neuroprotection and functional recovery after spinal cord injury. Biomaterials. 112: 62-71. PMID: 27744221

Hou S, Carson DM, Wu D, Klaw MC, Houle JD, Tom VJ (2016). Dopamine is produced in the rat spinal cord and regulates micturition reflex after spinal cord injury. Exp Neurol. 285: 136-146. PMID: 26655672

Wu D, Klaw MC, Kholodilov N, Burke RE, Detloff MR, Cote MP, Tom VJ (2016). Expressing constitutively active Rheb in adult dorsal root ganglion neurons enhances the integration of sensory axons that regenerate across a chondroitinase-treated dorsal root entry zone following dorsal root crush. Front Molec Neurosci. 9:49. PMID: 27458339

Mironets E, Wu D, Tom VJ (2016). Manipulating extrinsic and intrinsic obstacles to axonal regeneration after spinal cord injury. Neural Regen Res. 11: 225-225. PMID: 27073365

Partida E, Mironets E, Hou S, Tom VJ (2016).  Cardiovascular dysfunction following spinal cord injury.  Neural Regen Res. 11: 189-194. PMID: 27073353

Wu D, Klaw MC, Connors T, Kholodilov N, Burke RE, Tom VJ (2015).  Expressing constitutively-active Rheb in adult neurons after a complete spinal cord injury enhances axonal regeneration beyond a chondroitinase-treated glial scar.  J Neurosci. 35:11068-11080. PMID: 26245968

Chen X, Klaw MC, Lemay MA, Baas PW, Tom VJ (2015).  Pharmacologically inhibiting kinesin-5 activity with monastrol promotes axonal regeneration following spinal cord injury. Exp Neurol. 263: 172-176. PMID: 25447935

Ollivier-Lanvin K, Fischer I, Tom V, Houlé JD, Lemay MA (2015).  Either BDNF or NT-3 only neurotrophin producing grafts promote locomotor recovery in untrained cats.  Neurorehabilitation and Neural Repair. 29: 90-100. PMID: 24803493.

Hou S, Tom VJ, Graham L, Lu P, Blesch A (2013). “Partial restoration of cardiovascular function by embryonic neural stem cell grafts after complete spinal cord transection”.  J. Neurosci. 33:17138-17149. PMID: 24155317.

Klaw MC, Xu C, Tom VJ (2013). Intraspinal AAV injections immediately rostral to a thoracic spinal cord injury site efficiently transduces neurons in spinal cord and brain.  Mol. Ther. Nucl. Acids. 2: e108. PMID: 23881451

Tom VJ and Houlé JD (2013). "Peripheral nerve graft mediated axonal regeneration" in Neural Regeneration, So KF, Xu XM, Eds. (Science Publishing House, Shanghai).

Tom VJ, Sandrow-Feinberg HR, Miller K, Bouyer J, Zhukareva V, Domitrovich C, Lemay MA, Houlé JD (2013).  Exogenous BDNF enhances function of axons regenerating through a peripheral nerve “bridge” grafted into a chondroitinase-treated spinal cord injury site.  Exp Neurol. 239:91-100. PMID: 23022460

Comolli N, Donaldson O, Grantier N, Zhukareva V, and Tom VJ (2012).  PVA-PVP thin films provide local short-term release of anti-inflammatory agents post spinal cord injury.  J Biomed Materials Res. 100B(7): 1867-73. PMID: 22821814

Côté MP, Amin AA, Tom VJ, Houlé JD (2011).  Peripheral nerve grafts support regeneration after spinal cord injury.  Neurotherapeutics. 8:294-303. PMID: 21360238

Tom VJ, Sandrow-Feinberg HR, Miller K, Santi L, Connors T, Lemay MA, Houlé JD (2009).  Combining peripheral nerve grafts and chondroitinase promotes functional axonal regeneration in the chronically injured spinal cord.  J Neurosci. 29:14881-90. (Selected as a highlighted article for “This Week in the Journal”; highlighted and recommended by “Faculty of 1000”). PMID: 19940184

Houlé JD, Amin A, Cote MP, Lemay M, Miller K, Sandrow H, Santi L, Shumsky J, Tom V (2009). Combining peripheral nerve grafting and matrix modulation to repair the injured rat spinal cord. J Vis Exp. 2009 (33). pii: 1324. doi: 10.3791/1324. PMID: 19935638

Tom VJ, Kadakia R, Santi L, Houlé JD (2009).  Administration of chondroitinase ABC rostral or caudal to a spinal cord injury site promotes anatomical but not functional plasticity.  J Neurotrauma 26:2323-33. PMID: 19659409

Tom VJ, Houlé JD (2008).  Intraspinal microinjection of chondroitinase ABC following injury promotes axonal regeneration out of a peripheral nerve graft bridge.  Exp Neurol. 211: 315-9. PMID: 18353313

Houlé JD, Tom VJ, Mayes D, Wagoner G, Phillips N, Silver J (2006).  Combining an autologous peripheral nervous system "bridge" and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cord.  J Neurosci. 26: 7405-7415. (Recommended by “Faculty of 1000”). PMID: 16837588

Steinmetz MP, Horn KP, Tom VJ, Miller JH, Busch SA, Nair D, Silver DJ, Silver J (2005).  Chronic enhancement of the intrinsic growth capacity of sensory neurons combined with the degradation of inhibitory proteoglycans allows functional regeneration of sensory axons through the dorsal root entry zone in the mammalian spinal cord. J Neurosci. 25: 8066-8076. (Selected as a highlighted article for “This Week in the Journal”). PMID: 16135764

Tom VJ, Doller CM, Malouf AT, Silver J (2004).  Astrocyte-associated fibronectin is critical for axonal regeneration in adult white matter.  J Neurosci. 24: 9282-9290. (Selected as a highlighted article for “This Week in the Journal”). PMID: 15496664

Tom VJ, Steinmetz MP, Miller JH, Doller CM, Silver J (2004).  Studies on the development and behavior of the dystrophic growth cone, the hallmark of regeneration failure, in an in vitro model of the glial scar and after spinal cord injury.  J Neurosci. 24: 6531-6539. (Selected as a highlighted article for “This Week in the Journal”). PMID: 15269264

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